vCJD transfusion-associated Fourth Case UK

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Location: BACLIFF, Texas, United States

My mother was murdered by what I call corporate and political homicide i.e. FOR PROFIT! she died from a rare phenotype of CJD i.e. the Heidenhain Variant of Creutzfeldt Jakob Disease i.e. sporadic, simply meaning from unknown route and source. I have simply been trying to validate her death DOD 12/14/97 with the truth. There is a route, and there is a source. There are many here in the USA. WE must make CJD and all human TSE, of all age groups 'reportable' Nationally and Internationally, with a written CJD questionnaire asking real questions pertaining to route and source of this agent. Friendly fire has the potential to play a huge role in the continued transmission of this agent via the medical, dental, and surgical arena. We must not flounder any longer. ...TSS

Friday, November 20, 2009

SaBTO Advisory Committee on the Safety of Blood, Tissues and Organs Summary of the Eighth Meeting, 27 October 2009

SaBTO Advisory Committee on the Safety of Blood, Tissues and Organs Summary of the Eighth Meeting, 27 October 2009


Summary of the Eighth Meeting, 27 October 2009

1. Consent for blood transfusion

Members were reminded that questionnaires regarding informed consent for blood transfusion had been finalised by a working group consisting of SaBTO members and other experts. Two questionnaires have been developed which are specifically for either Healthcare Professionals or Patient groups. The working group had agreed the management of the consultation process with the Department of Health. The consultation process will be UK wide. Participants will be given 12 weeks to respond, after which time the consultation will close and the responses will be analysed.

2. MSBTO Guidance update

Members noted the urgent need for this update, which was expected to be forthcoming shortly.

3. Prion Filtration

Members had discussed prion filtration at previous meetings, and had asked to be kept updated on progress of both efficacy and safety assessments. This was provided via a presentation from the vCJD working group, with new data from both the ongoing clinical trial to assess safety of prion filtered red blood cells (the PRISM trial) and independent efficacy assessments of the performance of the same product. Early results from the clinical trial are encouraging, but members noted that the trial is still some way from completion. Members were appraised of data from the Health Protection Agency’s independent evaluation of efficacy, in addition to information from the manufacturer and another independent study. The committee noted that independent data from animal based, endogenous studies of efficacy will not be available until 2014. Having considered the information and analysis provided, the committee:

• is satisfied that there is now sufficient evidence that this particular filter reduces infectivity;

• recommends that filtered red cells be provided to those born since 1 January 1996, subject to satisfactory completion of the PRISM clinical trial.

The committee also noted that, if implemented, the continuing requirement for prion filtration should be reviewed in the event that either further data on prevalence or efficacy of the filters becomes available.

1

The committee had previously recommended the introduction of double dose red cells (DDRC) as a vCJD risk-reduction measure for under 16s and patients with haemoglobinopathies. SaBTO recommended that DDRC be rescinded for those groups receiving prion filtered blood.

2

http://www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/@dh/@ab/documents/digitalasset/dh_108860.pdf



Tuesday, November 11, 2008

SaBTO Summary of 1st Public Meeting – variant CJD and blood Tuesday 21st October 2008, 2pm-4pm

http://vcjdblood.blogspot.com/2008/11/sabto-summary-of-1st-public-meeting.html



Tuesday, October 27, 2009 AMORFIX DETECTS vCJD PRIONS IN BLOOD FROM NON-HUMAN PRIMATES

NEWS RELEASE TSX: AMF

FOR IMMEDIATE RELEASE

http://vcjdtransfusion.blogspot.com/2009/10/amorfix-detects-vcjd-prions-in-blood.html



TSEAC MEETING FEBRUARY 12, 2004 THE BAXTER STUDY GSS

http://tseac.blogspot.com/2009/09/tseac-meeting-february-12-2004-baxter.html



Sunday, May 10, 2009

Meeting of the Transmissible Spongiform Encephalopathies Committee On June 12, 2009 (Singeltary submission)

http://tseac.blogspot.com/2009/05/meeting-of-transmissible-spongiform.html


SEE UPDATED DATA ON BLOOD AND CJD HERE ;

Tuesday, November 17, 2009

SEAC EFFECT OF AGE ON THE PATHOGENESIS OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES SEAC 103/2

http://downercattle.blogspot.com/2009/11/seac-effect-of-age-on-pathogenesis-of.html




Tuesday, November 17, 2009

SEAC NEW RESULTS ON IDIOPATHIC BRAINSTEM NEURONAL CHROMATOLYSIS (IBNC) FROM THE VETERINARY LABORATORIES AGENCY (VLA) SEAC 103/1

http://bse-atypical.blogspot.com/2009/11/seac-new-results-on-idiopathic.html






TSS

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Wednesday, November 04, 2009

Detection of PrPsc in Blood from Sheep Infected with the Scrapie and Bovine Spongiform Encephalopathy Agents

Detection of PrPsc in Blood from Sheep Infected with the Scrapie and Bovine Spongiform Encephalopathy Agents


L. A. Terry,1* L. Howells,1 J. Hawthorn,1 J. C. Edwards,1 S. J. Moore,2 S. J. Bellworthy,2 H. Simmons,3 S. Lizano,4 L. Estey,4 V. Leathers,4 and S. J. Everest1 Department of Molecular Pathogenesis and Genetics,1 Department of Neuropathology,2 Animal Service Unit, Veterinary Laboratories Agency, Woodham Lane, New Haw, Surrey KT15 3NB, United Kingdom,3 IDEXX Corporation, Westbrook Drive, Portland, Maine4

Received 12 February 2009/ Accepted 31 August 2009

The role of blood in the iatrogenic transmission of transmissible spongiform encephalopathy (TSE) or prion disease has become an increasing concern since the reports of variant Creutzfeldt-Jakob disease (vCJD) transmission through blood transfusion from humans with subclinical infection. The development of highly sensitive rapid assays to screen for prion infection in blood is of high priority in order to facilitate the prevention of transmission via blood and blood products. In the present study we show that PrPsc, a surrogate marker for TSE infection, can be detected in cells isolated from the blood from naturally and experimentally infected sheep by using a rapid ligand-based immunoassay. In sheep with clinical disease, PrPsc was detected in the blood of 55% of scrapie agent-infected animals (n = 80) and 71% of animals with bovine spongiform encephalopathy (n = 7). PrPsc was also detected several months before the onset of clinical signs in a subset of scrapie agent-infected sheep, followed from 3 months of age to clinical disease. This study confirms that PrPsc is associated with the cellular component of blood and can be detected in preclinical sheep by an immunoassay in the absence of in vitro or in vivo amplification.

-------------------------------------------------------------------------------- * Corresponding author. Mailing address: Department of Molecular Pathogenesis and Genetics, Veterinary Laboratories Agency, Woodham Lane, New Haw, Surrey KT15 3NB, United Kingdom. Phone: (44) 1932-357533. Fax: (44) 1932-359525. E-mail: l.terry@vla.defra.gsi.gov.uk

Published ahead of print on 9 September 2009.

-------------------------------------------------------------------------------- Journal of Virology, December 2009, p. 12552-12558, Vol. 83, No. 23 0022-538X/09/$08.00+0 doi:10.1128/JVI.00311-09 Copyright © 2009, American Society for Microbiology. All Rights Reserved.



http://jvi.asm.org/cgi/content/abstract/83/23/12552?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=prion&searchid=1&FIRSTINDEX=0&volume=83&issue=23&resourcetype=HWCIT





http://vcjdtransfusion.blogspot.com/





TSS

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